Angiotensin-converting enzyme (ACE) inhibitors – Mayo Clinic

Angiotensin-changing enzyme (ACE) inhibitors

These medication are usually prescribed to deal with high blood force, heart challenges and a lot more.

By Mayo Clinic Workers

Angiotensin-changing enzyme (ACE) inhibitors are medications that aid relax the veins and arteries to lower blood force. ACE inhibitors prevent an enzyme in the body from making angiotensin II, a material that narrows blood vessels. This narrowing can trigger high blood force and forces the heart to operate more durable. Angiotensin II also releases hormones that elevate blood force.

Illustrations of ACE inhibitors

A lot of ACE inhibitors are out there. The best 1 for you depends on quite a few factors, which include your overall overall health and present ailments. For example, people today with serious kidney sickness may perhaps gain from having an ACE inhibitor as 1 of their medications.

Illustrations of ACE inhibitors involve:

  • Benazepril (Lotensin)
  • Captopril
  • Enalapril (Vasotec)
  • Fosinopril
  • Lisinopril (Prinivil, Zestril)
  • Moexipril
  • Perindopril
  • Quinapril (Accupril)
  • Ramipril (Altace)
  • Trandolapril

When ACE inhibitors are used

ACE inhibitors are used to prevent, deal with or improve signs and symptoms in ailments this sort of as:

  • Large blood force (hypertension)
  • Coronary artery sickness
  • Coronary heart failure
  • Diabetes
  • Certain serious kidney disorders
  • Coronary heart attacks
  • A sickness that includes hardening of the pores and skin and connective tissues (scleroderma)
  • Migraines

Often, a different blood force medicine — this sort of as a diuretic or calcium channel blocker — is prescribed with an ACE inhibitor. ACE inhibitors shouldn’t be taken with an angiotensin receptor blocker or with a immediate renin inhibitor.

Aspect consequences

Aspect consequences of ACE inhibitors may perhaps involve:

  • Dry cough
  • Amplified potassium stages in the blood (hyperkalemia)
  • Exhaustion
  • Dizziness from blood force going much too lower
  • Head aches
  • Loss of flavor

Almost never, ACE inhibitors can trigger some places of the tissues to swell (angioedema). If swelling takes place in the throat, it can be lifestyle-threatening.

Nonsteroidal anti-inflammatory medication (NSAIDs), this sort of as ibuprofen (Advil, Motrin IB, other individuals) and naproxen sodium (Aleve), reduce the success of ACE inhibitors. Getting an occasional dose of these medications shouldn’t have an impact on how an ACE inhibitor will work, but chat to your health practitioner if you on a regular basis get NSAIDs.

Getting ACE inhibitors during pregnancy increases the possibility of start defects in the toddler. If you’re pregnant or system to turn out to be pregnant, chat to your health practitioner about other selections to deal with high blood force.