March 9, 2022 — David Bennett Sr., the 57-calendar year-old patient with terminal heart condition who turned the to start with man or woman to receive a genetically modified pig coronary heart, has died.

Bennett handed absent Tuesday, in accordance to a statement from the College of Maryland Professional medical Heart in Baltimore, the place the transplant was done.

Bennett acquired the transplant on Jan. 7 and lived for 2 months following it.

Despite the fact that not giving the precise lead to of his death, the professional medical centre reported Bennett’s condition began having even worse a number of times prior to his demise.

When it became very clear that he would not recuperate, he was supplied compassionate palliative treatment and was ready to talk with his family through his ultimate several hours.

“We are devastated by the reduction of Mr. Bennett. He proved to be a courageous and noble affected individual who fought all the way to the stop. We prolong our sincerest condolences to his loved ones,” Bartley P. Griffith, MD, who executed the transplant, stated in the statement.

“We are grateful to Mr. Bennett for his one of a kind and historic part in encouraging to add to a vast array of awareness to the field of xenotransplantation,” which is the process of transplanting organs involving diverse species, reported Muhammad M. Mohiuddin, MD, director of the cardiac xenotransplantation system at University of Maryland University of Drugs.

Ahead of obtaining the genetically modified pig coronary heart, Bennett desired mechanical support to remain alive but was turned down for a conventional heart transplant at the University of Maryland Healthcare Heart and other facilities.

Following the operation, the transplanted pig coronary heart done well for numerous weeks without any signs of rejection. Bennett was in a position to devote time with his household and do physical therapy to aid get back power.

“This organ transplant shown for the very first time that a genetically modified animal coronary heart can functionality like a human heart with out fast rejection by the body,” the healthcare centre reported in a assertion 3 times immediately after the surgical procedure.

Thanks to Bennett, “we have obtained invaluable insights finding out that the genetically modified pig heart can operate properly within the human entire body when the immune process is sufficiently suppressed,” reported Mohiuddin.

“We stay optimistic and system on continuing our function in upcoming scientific trials,” he mentioned.

Bennett’s son, David Bennett Jr, claimed the family members is “profoundly grateful for the daily life-extending chance” presented to his father by the “stellar team” at the College of Maryland Faculty of Medicine and the University of Maryland Clinical Heart.

“We had been capable to spend some precious months collectively when he recovered from the transplant surgical procedures, months we would not have experienced devoid of this miraculous exertion,” Bennett Jr. mentioned.

“We also hope that what was discovered from his surgical procedures will reward upcoming sufferers and with any luck , 1 day, conclude the organ shortage that prices so numerous lives each individual 12 months,” he stated.