St. John’s wort – Mayo Clinic

Overview

St. John’s wort (Hypericum perforatum) is a flowering shrub indigenous to Europe. It will get its name from the point that it typically blooms on the birthday of the biblical John the Baptist.

The flowers and leaves of St. John’s wort incorporate energetic substances these as hyperforin. St. John’s wort is offered as a complement in teas, tablets, liquids and topical preparations.

Men and women use St. John’s wort to address melancholy and menopausal indicators.

Proof

Study on St. John’s wort use for precise disorders demonstrates:

  • Despair. A number of experiments aid the therapeutic profit of St. John’s wort in managing moderate to reasonable melancholy. In point, some analysis has revealed the complement to be as successful as a number of prescription antidepressants. It can be unclear whether it really is valuable in the cure of intense melancholy. Simply because St. John’s wort interacts with lots of drugs, it may well not be an acceptable choice, especially if you choose any prescription medication.
  • Menopausal indicators. Some evidence indicates that having St. John’s wort alone or in blend with black cohosh or other herbs may well lessen menopausal indicators these as very hot flashes.
  • Somatic symptom dysfunction. Some experiments show that St. John’s wort may well be valuable for the cure of this affliction that leads to intense panic about bodily indicators these as discomfort, weakness or shortness of breath.

Our choose

Yellow light: Caution

Warning

St. John’s wort can be successful for managing moderate to reasonable melancholy. Having said that, the complement interacts with lots of drugs and can induce major aspect results. Seek advice from with your medical professional right before having St. John’s wort if you choose any other drugs.

Protection and aspect results

When taken orally for up to twelve weeks in acceptable doses, St. John’s wort is frequently regarded as risk-free. Having said that, it may induce:

  • Agitation and panic
  • Dizziness
  • Diarrhea, constipation and belly pain
  • Dry mouth

Other aspect results may include things like:

  • Tiredness and sleeplessness
  • Headache
  • Amplified sensitivity to sunlight (photosensitivity)

There is not enough info about the basic safety of applying St. John’s wort topically.

Really don’t use St. John’s wort through pregnancy or while breastfeeding.

Interactions

The checklist below consists of some recognized interactions. Having said that, other medication may also interact with St. John’s wort. Check out with your medical professional right before applying St. John’s wort in blend with any other medication, specifically prescription drugs.

  • Alprazolam (Xanax). Getting St. John’s wort with this drug made use of to alleviate indicators of panic may well decrease the drug’s influence.
  • Antidepressants. Getting St. John’s wort with antidepressants may well improve the threat of the accumulation of high degrees of serotonin in your physique. Much too a great deal serotonin can induce moderate to intense aspect results. Getting this complement and an antidepressant demands a doctor’s supervision.
  • Barbiturates. Getting St. John’s wort with a drug that functions as a central anxious procedure depressant (barbiturate) may well decrease barbiturate-induced sleep time.
  • Bupropion (Wellbutrin SR, Forfivo XL). Getting St. John’s wort with this antidepressant may well decrease the drug’s influence.
  • Specific chemotherapy medication. Getting St. John’s wort with irinotecan (Camptosar, Onivyde), docetaxel (Taxotere) or imatinib (Gleevec) may well lessen the chemotherapy drug’s results.
  • Specific immunosuppressive medication. Getting St. John’s wort with tacrolimus (Prograf, Astagraf XL, others) or cyclosporine (Neoral, Sandimmune, others) may well decrease the drug’s influence.
  • Specific statins. Getting St. John’s wort with simvastatin (Zocor, Flolipid) may well lessen the drug’s usefulness.
  • Contraceptive medication. Use of St. John’s wort with contraceptive medication may well consequence in breakthrough bleeding, irregular bleeding or unplanned pregnancy. An further or alternative variety of birth control may well be needed.
  • Cytochrome P450 1A2 (CYP1A2), Cytochrome P450 2B6 (CYP2B6), Cytochrome P450 2C19 (CYP2C19) and cytochrome P450 2C9 (CYP2C9) and cytochrome P450 3A4 (CYP3A4) substrates. Really don’t choose St. John’s wort if you might be having a drug afflicted by these enzymes.
  • Dextromethorphan. Getting St. John’s wort with this cough suppressant may well improve the threat of the accumulation of high degrees of serotonin in your physique.
  • Digoxin (Lanoxin). Getting St. John’s wort with this coronary heart treatment can lessen the drug’s influence.
  • Fexofenadine (Allegra Allergy). Getting St. John’s wort with this antihistamine may well induce way too a great deal of the drug to create up in your physique, worsening typical aspect results.
  • Ketamine (Ketalar). Getting St. John’s wort with ketamine may well lessen the drug’s anesthetic influence.
  • Narcotics. Really don’t choose St. John’s wort with methadone (Methadose). Getting St. John’s wort with selected narcotics may well lessen the drug’s usefulness. Combining the complement with narcotics may well also improve narcotic-induced sleep time and painkilling results.
  • Non-nucleoside reverse transcriptase inhibitors. Getting St. John’s wort with 1 of these anti-HIV medication could lessen the drug’s influence.
  • Omeprazole (Prilosec). Really don’t choose St. John’s wort with this drug made use of to address persistent heartburn. The complement can lessen the drug’s usefulness.
  • Phenytoin (Dilantin, Phenytek). Getting St. John’s wort with this anticonvulsant may well consequence in decline of seizure control.
  • Photosensitizing medication. Getting St. John’s wort with a drug that raises sensitivity to sunlight may well improve the threat of a reaction.
  • Protease inhibitors. Getting St. John’s wort with this type of antiviral drug can lessen the drug’s usefulness.
  • Triptans. Really don’t choose St. John’s wort with these drugs made use of to address migraines. The complement may well improve the threat of the accumulation of high degrees of serotonin in your physique. Much too a great deal serotonin can induce moderate to intense aspect results.
  • Voriconazole. Getting St. John’s wort with this antifungal drug may well lessen the drug’s usefulness.
  • Warfarin (Jantoven). Getting St. John’s wort with this drug taken to lessen blood clotting may well decrease the drug’s influence.

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